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Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor


  • Jamie R K Marland
  • Mark E Gray
  • Camelia Dunare
  • Ewen O Blair
  • Andreas Tsiamis
  • Paul Sullivan
  • Eva González-Fernández
  • Stephen N Greenhalgh
  • Rachael Gregson
  • R Eddie Clutton
  • Magdalena M Parys
  • Alex Dyson
  • Mervyn Singer
  • Ian H Kunkler
  • Mark A Potter
  • Srinjoy Mitra
  • Jonathan G Terry
  • Stewart Smith
  • Andrew R Mount
  • Ian Underwood
  • Anthony J Walton
  • David J Argyle
  • Alan F Murray



Implantable, Microfabrication, Oxygen sensor, Tumour hypoxia


Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.


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