Preprint has been published in a journal as an article
DOI of the published article https://doi.org/10.1021/acs.iecr.2c01217

Preprint / Version 1

Mobile On Demand COVID-19 Vaccine Production Units for Developing Countries

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Steffen Fahr a) RWTH Aachen University, 52074 Aachen, Germany; g) Institute of Plant and Process Technology, Technical University of Munich, 85748 Garching, Germany; Process Systems Engineering (AVT.SVT) https://orcid.org/0000-0002-0817-7877
Samantha Ayde Peña-Benavides b) Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark; d) Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, 64849, Mexico https://orcid.org/0000-0002-4408-976X
Lukas Thiel a) Process Systems Engineering (AVT.SVT), RWTH Aachen University, 52074 Aachen, Germany https://orcid.org/0000-0002-3746-4664
Carl Sengoba a) Process Systems Engineering (AVT.SVT), RWTH Aachen University, 52074 Aachen, Germany
Kaan Karacasulu a) RWTH Aachen University, 52074 Aachen, Germany; g) Institute of Plant and Process Technology, Technical University of Munich, 85748 Garching, Germany; Process Systems Engineering (AVT.SVT) https://orcid.org/0000-0003-2901-8741
Dr. Nina Ihling c) Biochemical Engineering (AVT.BioVT), RWTH Aachen University, 52074 Aachen, Germany https://orcid.org/0000-0002-5242-3641
Dr. Juan Eduardo Sosa-Hernández d) Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, 64849, Mexico https://orcid.org/0000-0001-5441-4768
Dr. Gary Gilleskie f) Golden LEAF Biomanufacturing Training and Education Center (BTEC), NC State University, 27606 Raleigh, NC, USA https://orcid.org/0000-0002-5016-6370
Dr. John M. Woodley b) Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark https://orcid.org/0000-0002-7976-2483
Dr. Roberto Parra-Saldivar d) Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey, 64849, Mexico https://orcid.org/0000-0002-4958-5797
Dr. Seyed Soheil Mansouri b) Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark https://orcid.org/0000-0002-0924-4947
Dr. Kosan Roh a) Process Systems Engineering (AVT.SVT), RWTH Aachen University, 52074 Aachen, Germany; e) Department of Chemical Engineering and Applied Chemistry, Chungnam National University, 34141 Daejeon, Republic of Korea https://orcid.org/0000-0002-4918-4782

DOI:

https://doi.org/10.31224/2199

Keywords:

COVID-19, Vaccine Manufacture, Mobile on Demand Production, Decentralised manufacture, Biopharmaceuticals

Abstract

Almost two years into the COVID-19 pandemic and one year after the approval of the first vaccine, bottlenecks in production and supply chain infrastructure continue to delay vaccination campaigns in the Global South. Mobile on Demand (MOD) vaccine manufacture may help quickly ramp up production capacity while bypassing infrastructure bottlenecks. Such decentralised small-scale factories can help tip the scales in the battle against COVID-19 and future pandemics. In this work, we designed two MOD vaccine manufacturing units based on a protein antigen expressed in yeast and in vitro transcription of mRNA. Each unit consists of two shipping containers and allows to produce on the order of 10,000 vaccine doses daily for competitive prices and in close proximity of their end users. Abandoning economies of scale may lead to a moderate increase in production costs that may be outweighed by reduced closed-vial dose wastage and an earlier protection of vulnerable populations.

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Author Biography

Steffen Fahr, a) RWTH Aachen University, 52074 Aachen, Germany; g) Institute of Plant and Process Technology, Technical University of Munich, 85748 Garching, Germany; Process Systems Engineering (AVT.SVT)

Research Associate, TUM School of Engineering and Design

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Posted

2022-03-03

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Copyright (c) 2022 Steffen Fahr, Samantha Ayde Peña-Benavides, Lukas Thiel, Carl Sengoba, Kaan Karacasulu, Dr. Nina Ihling, Dr. Juan Eduardo Sosa-Hernández, Dr. Gary Gilleskie, Dr. John M. Woodley, Dr. Roberto Parra-Saldivar, Dr. Seyed Soheil Mansouri, Dr. Kosan Roh