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Preprint / Version 1

Injectable peptide-glycosaminoglycan hydrogels for soft tissue repair: in vitro assessment for nucleus augmentation

##article.authors##

  • James Warren University of Leeds
  • Ruth Coe University of Leeds
  • Matthew Culbert University of Leeds
  • Andrew Dixon University of Leeds
  • Danielle Miles University of Leeds
  • Marlène Mengoni University of Leeds
  • Paul Beales University of Leeds
  • Ruth Wilcox University of Leeds

DOI:

https://doi.org/10.31224/2931

Keywords:

self-assembled structures, hydrogel, Biomedical engineering, Medical Device, Biomedical materials

Abstract

We report the development of peptide-glycosaminoglycan hydrogels as injectable biomaterials for load-bearing soft tissue repair. The hydrogels are injectable as a liquid for clinical delivery, rapidly form a gel in situ, and mimic the osmotic swelling behaviour of natural tissue. We use a new in vitro model to demonstrate their application as a nucleus augmentation material for the treatment of intervertebral disc degeneration.

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Posted

2023-04-07

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Copyright (c) 2023 James Warren, Ruth Coe, Matthew Culbert, Andrew Dixon, Danielle Miles, Marlène Mengoni, Paul Beales, Ruth Wilcox

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.