Preprint has been published in a journal as an article
DOI of the published article https://doi.org/10.1038/s41380-024-02567-9
Preprint / Version 1

On assumptions and key issues in electric field modeling in ECT

##article.authors##

  • Zhi-De Deng National Institute of Mental Health
  • Miklos Argyelan
  • Jeremy Miller
  • Davin Quinn
  • Megan Lloyd
  • Thomas Jones
  • Joel Upston
  • Erik Erhardt
  • Shawn McClintock
  • Abhishek Datta
  • Christopher Abbott

DOI:

https://doi.org/10.31224/3190

Keywords:

Electric field modeling, finite element method, electrical stimulation

Abstract

Recently, Dr. Alexander Sartorius commented on our work [1] on assessing relationships between electric field (E-field) strength, hippocampal volume change, and electroconvulsive therapy (ECT) clinical outcomes [2]. Dr. Sartorius questioned the applicability of E-field modeling for ECT based on 1) temporal waveform dependence; 2) tissue impedance dependence; and 3) tissue anisotropy dependence. We appreciate these considerations and agree that E-field modeling would benefit from further validation and improvement. However, we need to point out misconceptions of E-field modeling assumptions and delineate some key issues involved.

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Posted

2023-08-23

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Copyright (c) 2023 Zhi-De Deng, Miklos Argyelan, Jeremy Miller, Davin Quinn, Megan Lloyd, Thomas Jones, Joel Upston, Erik Erhardt, Shawn McClintock, Abhishek Datta, Christopher Abbott

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.