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Porous elastic composite scaffolds based on enzymatically synthesized poly(glycerol adipate) and bioglass: the effect of L-lysine diisocyanate content on crosslinking degree and mechanical properties

##article.authors##

  • Konrad Szustakiewicz Wrocław University of Science and Technology https://orcid.org/0000-0002-2855-852X
  • Michał Grzymajło Department of Polymer Engineering and Technology, Faculty of Chemistry, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Anna Krokos Department of Polymer Engineering and Technology, Faculty of Chemistry, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Magdalena Kobielarz Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Ewelina Ortyl Department of Polymer Engineering and Technology, Faculty of Chemistry, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Anna Nikodem Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland
  • Lidia Ciołek Biomaterials Research Group, Ceramic and Concrete Division in Warsaw, Łukasiewicz Research Network Institute of Ceramics and Building Materials, Postępu 9, 02-676 Warsaw, Poland
  • Monika Biernat Biomaterials Research Group, Ceramic and Concrete Division in Warsaw, Łukasiewicz Research Network Institute of Ceramics and Building Materials, Postępu 9, 02-676 Warsaw, Poland
  • Sylwia Rodziewicz-Motowidło Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland
  • Artur Oziębło 5Mossakowski Medical Research Institute, Polish Academy of Sciences, A. Pawińskiego 5, 02-106 Warsaw
  • Małgorzata Gazińska Department of Polymer Engineering and Technology, Faculty of Chemistry, Wrocław University of Science and Technology (WUST), Wyb. Wyspiańskiego 27, 50-370 Wrocław, Poland

DOI:

https://doi.org/10.31224/4457

Keywords:

poly(glycerol adipate), thermally induced phase separation, scaffolds, mechanical properties, LDI, chemical crosslinking, composite materials, bioglass

Abstract

In this research, poly(glycerol adipate) prepolymer (pPGA) was synthetized using enzymatic polymerization of divinyl adipate (DVA) and glycerol in reaction carried out in the presence of Candida Antarctica enzyme. The pPGA was then solved in 1,4-dioxane and mixed with L-lysine diisocyanate (LDI), bioglass, pourged into mold with sodium chloride, cured and freeze-dried. LDI has a dual function in the system: it is a cross-linking agent and also a bioactive agent that is chemically bound to the scaffold. Three types of porous composite scaffolds having 20 wt.% of bioglass and different cross-linking degree (25, 50 and 100 mol% of LDI) were investigated. The scaffolds were characterized by means of porosity, density, SEM. All tested materials were subjected to a quasi - static compression test. Each material was compressed 10 times. It was shown that the materials exhibited a return to their original shape even with a large compression strain of 90%. An imaging study of the scaffolds before and after compression was conducted using computed tomography (CT). The CT study showed that the resulting materials were not significantly mechanically damaged in the multi - compression process.

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Posted

2025-03-25

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Copyright (c) 2025 Konrad Szustakiewicz, Michał Grzymajło, Anna Krokos, Magdalena Kobielarz, Ewelina Ortyl, Anna Nikodem, Lidia Ciołek, Monika Biernat, Sylwia Rodziewicz-Motowidło, Artur Oziębło, Małgorzata Gazińska

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This work is licensed under a Creative Commons Attribution 4.0 International License.