Tissue Mechanics as a Predictor for Saccular Aneurysm Rupture

Abstract

Intracranial saccular aneurysms are highly prevalent in the western world. Although rupture occurs in a only small number of aneurysms, the mortality rate associated with this event is significant. Thus due to the high risk associated with rupture and the risks of rupture repair surgery it is desirable to be able to predict whether a specific aneurysm is likely to rupture or will instead stabilize. Research into aneurysm development has shown that the response cannot be quantified with simple mechanical models alone. It is also necessary to consider growth and remodeling of the tissue constituents and complex geometric stress concentrators as well. Through the production of complete aneurysm development models, it may be possible to enable accurate prediction of aneurysm rupture based on clinically observable measures such as aneurysm geometry and growth rates. This would help to minimize the use of risky and unnecessary repair surgeries for aneurysms which would ultimately stabilize naturally.